- As of yet, no single therapeutic intervention has been found to impact Alzheimer’s disease. Whereas other diseases, such as cancer and HIV treatment have required a multi-modal intervention, why shouldn’t Alzheimer’s?
- Alzheimer’s disease (AD) results, in part, from a failure of synapse formation (called neuronal plasticity), which allows brain cells to connect with each other to preserve memory and basic functions. Instead, in AD, there is an increase in breakdown products on the right side of the diagram above, that cause less neurons to connect.
- The goal of therapy may be to increase the trophic, anti-AD processing, leading to more neurons connecting and thus preventing Alzheimer’s disease. This requires multiple medicines and processes to intervene. and succeed.
- A study listed in the link below demonstrated that using these interventions resulted in a reversal of memory loss and even a return to a employment in 10 individuals who followed the regimen. This reversal started in 3-6 months after initiation and remained for the duration of the study over two years.
- http://www.impactaging.com/index.html <– The link to the study. Great results!!
The therapeutic system:
- Optimize diet, minimize simple sugars to minimize inflammation. Eat Low glycemic, low grain diet. Minimize insulin resistance.
- Enhance ketogenesis by fasting 12 hours at night including three hours prior to bedtime. This reduces insulin levels and A-beta.
- Reduce stress through meditation or yoga, thereby reducing cortisol levels and stress,
- Optimize sleep – obtain 8 hours a night, use melatonin 0.5 mg at night and Tryptophan 500 mg three times a week. Get checked and treated for sleep apnea.
- Exercise 30-60 minutes a day for four-six days a week.
- Keep you brain active mentally through reading or mental exercises.
- Maintain your homocysteine levels to <7 – using methylcobalamin 1mg a day, methyltetrahydrofolate 0.8 mg a day, and pyridoxine-5-phosphate 50 mg a day. Consider taking trimethylglycine.
- Maintain serum B-12 above 500 by taking oral B-12 as above
- Keep the CRP<1 ( inflammation marker) using an anti-inflammatory diet that includes curcumin, DHA (docosahexanoic acid) 320 mg and EPA (eicosapentanoic acid) 180 mg a day
- Optimize fasting insulin <7 and keep the hemoglobin A1c <5.5 by following your diabetic diet precisely.
- Optimize your hormone balance, including your free T3 and T4, and estradiol, and testosterone levels. Be certain cortisol and progesterone/pregnenolone levels are in range through lab tests.
- GI health maintenance through probiotics use.
- Reduce A-beta through the use of cucumin and herbs such as Ashwagandha (500mg a day) and Bacopa Monniera (250 mg a day) and tumeric 400 mg a day.
- Cognitive enhancement through the use of Bacopa monniera and magnesium threonate.
- Vitamin D3 needs to be between 50-100 ng/ml by appropriate Vitamin D3 intake ( up to 2000 IU/day) and Vitamin K2.
- Increase NGF through intake of H. ernaceus or acetyl-L-carnitine.
- Provide synaptic structural components through citicoline 500 mg twice a day and DHA (docosohexanoic acid) 320 mg a day.
- Optimize antioxidants by intake of mixed tocopherols and tocotrienols, with selenium blueberries, n- acetyl cysteine, ascorbate, and alpha-lipoic acid. For example, use of vitamin C at 1 gram a day, Vitamin E at 400 IU a day, and alpha-lipoic acid a 100 mg a day.
- Optimize the zinc and copper ratio: if needed, , zinc picolinate at 50 mg a day may be needed, depending on the zinc levels.
- Treat sleep apnes as needed to maximize nighttime oxygenation.
- Optimize mitochondrial function through CoQ10 at 200 mg a day, alpha lipoic acid at 100 mg a day, polyquinoline quinone, N-acetyl cysteine, acetyl-L-carnitine, zinc, resverarol, thiamine and Vitamin C intake.
- Increase focus through pantothenic acid.
- Increase SirT1 function through Resveratrol intake.
- Exclude heavy metal toxicity and evaluate fo mercury, lead, cadmium toxicity.
- Reduce mMCT effects (medium chain triglycerides – a part of our diet) by taking coconut oil at a teaspoon three times a day or using Axona.
Obviously multiple lab test parameters are needed to determine needs and the interventions are quite rigorous, requiring a strict diet and lots of pills throughout the day, but this multi-modal intervention seems to work!
Lab tests that may be needed include: serum homocysteine, CRP, Vitamin D levels, Hemoglobin A1c, serum copper, serum zinc, ceruplasmin, pregnenolone, testosterone level, albumin:globulin ratio, cholesterol, morning cortisol, free T3 and T4 and TSH levels, DHEA levels, estradiol level, progesterone, insulin.
It is extensive but this seems to hold promise. More later!