Insane Medicine : Testosterone – who needs it?

Insane Medicine -Depo-Testosterone 200 mg per ml injection Testosterone cypionate
Testosterone
  • Testosterone is a hormone with many biological effects. It binds to androgen receptors in the body, or is converted to  dihydrotestosterone,(via the enzyme enzyme 5-alpha-reductase ), which then can bind to androgen receptors in the body. Testosterone can act like an estrogen as well after being converted to estradiol via an aromatase.
  • Dihydrotestosterone’s main action is on the external genitalia and prostate in men, while testosterone affects muscle maintenance and strength. The estradiol function of testosterone affects sexual functioning and decreases body fat in men. Likewise, it has an effect on bone mass.
Insane Medicine - The hypothalamus  releases a gonadotrophal releasing hormone that stimulates the pituitary to make FSH and LH that, in turn, stimulates the testiles to produce testosterone.
Insane Medicine – The hypothalamus releases a gonadotrophin releasing hormone that stimulates the pituitary to make FSH and LH that, in turn, stimulates the testicles to produce testosterone.
  • Symptoms suggestion androgen (testosterone) deficiency include low libido, loss of erections,  low bone mineral density, enlargement of the breasts, anemia, decreased muscle mass, decreased energy, and increased body fat.
  • The goal for testosterone replacement in males is to increase libido, muscle mass restoration, increase fat-free mass, increase bone density, and decrease body fat.
  • Testosterone should be measured in the morning on three different occasions, as there is a circadian rhythm in testosterone secretion. If it low each time and the patient has symptoms consistent with testosterone deficiency, then replacement would be indicated. Again,  low libido, decreased morning erections, loss of body hair, low bone mineral density (BMD), gynecomastia, and small testes suggest a need for treatment.
  • In appropriate candidates, testosterone replacement leads to improved muscle strength and fat-free mass. Bone density can also improve as well by as much as 40% in patients who are hypogonadal (low testosterone).
  • As for sexual dysfunction, Testosterone replacement may  increased sexual desires, but that maynot necessarily result an increased satisfaction rate.
  • Testosterone seems to render no improvement in cognitive abilities in patients.
  • Risks of testosterone replacement include the potential to increase the risk of prostate cancer, worsen sleep apnea, increased risk of venous thromboembolism (blood clots in the legs), andpotential increased cardiovascular risks.
  • Thus – using testosterone is best saved for those with clear indiciations. Consult your doctor. More later on all this.
Insane Medicine - Testosterone
Insane Medicine – Testosterone

 

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